Peter Seeberger

Guest Speaker

Prof. Dr. Peter Seeberger

Max Planck Institute of Colloids and Interfaces, Potsdam, Germany

Session: Chemical-Biological (Re-)Synthesis

Title: Continuous Flow Synthesis
of Medicines

Friday, March 4th 2022, 14:00 CET
Vita

Peter H. Seeberger studied chemistry in Erlangen (Germany) and completed a PhD in biochemistry in Boulder (USA). After a postdoctoral fellowship at the Sloan-Kettering Cancer Center Research in New York he advanced to tenured Firmenich Associate Professor of Chemistry at MIT. After six years as Professor at the Swiss Federal Institute of Technology (ETH) Zurich he assumed positions as Director at the Max-Planck Institute for Colloids and Interfaces in Potsdam and Professor at the Free University of Berlin in 2009. In addition, he serves as honorary Professor at the University of Potsdam. From 2003-2014 he was Affiliate Professor at the Sanford-Burnham Institute for Medical Research (La Jolla, USA). Since 2021, he is a Vice President of the German Research Foundation (DFG) the main funding body in Germany. He is a member of the governing body of the Max-Planck Society (“Senate”). Professor Seeberger’s research on the chemistry and biology of carbohydrates, carbohydrate vaccine development and continuous flow synthesis of drug substances spans a broad range of topics from engineering to immunology and has been documented in over 610 peer-reviewed journal articles, four books, more than 50 patents, over 200 published abstracts and more than 900 invited lectures. This work was recognized with more than 35 international awards from the US (e.g. Arthur C. Cope Young Scholar Award, Horace B. Isbell Award, Claude S. Hudson Award from the American Chemical Society), Germany (e.g. Körber Prize for European Sciences, Wissenschaftspreis des Stifterverbandes, Emil Fischer Medal), Holland (Havinga Medal), Israel (Honorary Lifetime Member Israel Chemical Society), Japan (Yoshimasa Hirata Gold Medal), Switzerland (“The 100 Most Important Swiss”), the Philippines (“Gusi Peace Prize”) and international organizations (Whistler Award 2012, Int. Carboh. Soc.). In 2013 he was elected to the Berlin-Brandenburg (Prussian) Academy of Sciences. Peter H. Seeberger greatly supports the idea of open access publishing as the Editor-in-Chief of the Beilstein Journal of Organic Chemistry and serves on the editorial advisory boards of many other journals. Through his work in the area of neglected diseases, Peter Seeberger has become involved in philanthropic causes. He is a co-founder of the Tesfa-Ilg “Hope for Africa” Foundation that aims at improving health care in Ethiopia that recently helped to build a bed-net factory and established an IT training center. The research in the Seeberger laboratory has given rise to nine successful companies in the USA, Switzerland, Denmark and Germany.

Abstract

Continuous Flow Synthesis of Medicines

Continuous flow chemistry1 is a useful approach for automated reaction optimization2 and the modular assembly of active pharmaceutical ingredients.3 A fully automated platform to prepare many essential medicines in a radial synthesizer has been developed.4 The method was applied to the synthesis of medications in short supply during the COVID-19 pandemic.5 The synthesis of the anti-malaria drug artemisinin and its derivatives is used to illustrate the principle.6 This complex molecule was prepared from plant waste, light and air and is now used in human clinical trials to treat cancer and viral infections.

  1. Plutschack, M.; Pieber, B.; Gilmore, K.; Seeberger, P.H.; Chem.Rev. 2017, 117, 11796-11893
  2. Chatterjee, S.; Moon, S.;  Hentschel, F.;  Gilmore, K.; Seeberger, P.H.; J. Am. Chem. Soc., 2018, 140, 11942.
  3. Ghislieri, D.; Gilmore, K.; Seeberger, P.H.; Angew. Chem. Int. Ed. 2015, 54, 678. 
  4. Chatterjee, S.; Guidi, M.; Seeberger, P.H.; Gilmore, K.; Nature 2020, 579, 379.
  5. Guidi, M.; Moon, S.; Anghileri, L.; Cambié, D.; Seeberger, P.H.; Gilmore, K.; Reaction Chemistry & Enginering. 2021, 6, 220.
  6. Levesque, F.; Seeberger, P.H. Angew. Chem. Int. Ed. 2012, 51, 1706; Triemer, S.; Gilmore, K.; Truong Vu, G.; Seeberger, P.H.; Seidel-Morgenstern, A.; Angew.Chem.Int.Ed. 2018, 57, 5525.

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